We reported results via a graphical assessment using forest plots showing the study estimates. We performed all analyses using Review Manager (RevMan) or the R meta package, and in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Three review authors, BC, JW, and RJ, independently extracted data using a standardized data sheet. We resolved any discrepancies regarding eligibility by discussion with a third review author, RA. Two review authors, BC and RJ, independently screened by title and abstract the studies we had identified through the search strategy when this was inconclusive, they examined the full‐text article for inclusion. We also handsearched recent conference proceedings and sought information from experts in the field. We searched the Cochrane Breast Cancer Group's (CBCG) Specialized Register, MEDLINE (via PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) search portal from the earliest available date up to 30 March 2015. To assess the therapeutic outcomes of any new form of guided surgical intervention for non‐palpable breast lesions against wire‐guided localization, the current gold standard. With the clinical setting shifting towards earlier non‐palpable breast lesions being detected through screening, we investigated whether the current standard in assisting surgical excision of these lesions, WGL, yields the best therapeutic outcome for women with breast cancer. Currently the most widely adopted approach (80% in one survey) in guided breast‐conserving surgery for excising non‐palpable breast lesions is wire‐guided localization (WGL). The challenge is to accurately locate small non‐palpable lesions intraoperatively for optimal therapeutic outcome. A secondary important goal is to remove the smallest amount possible of healthy glandular tissue for optimal cosmesis. Amongst five invasive cancers per 1000 women detected in screening, 2.7 were < 15 mm in diameter and others reported that over one third of excised breast lesions were clinically occult. Breast cancer is the most common form of cancer and the second leading cause of death amongst women in Europe.
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